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Recent Publications
Published at :2017/3/21

Title : Promising effect of rapamycin on multiple sclerosis


Abstract :


Published at :2017/3/21

Title : Transcultural Adaptation and Validation of Persian Version of Celiac Disease Questionnaire (CDQ); A Specific Questionnaire to Measure Quality of Life of Iranian Patients


Abstract :

Background: The assessment of health-related quality of life has become an important primary or secondary outcome measure in clinical and epidemiologic studies. The aim of this study was to validate a Persian version of Celiac Disease Questionnaire (CDQ) for Celiac disease (CD) among Iranian patients.


Publications

Promising effect of rapamycin on multiple sclerosis
Transcultural Adaptation and Validation of Persian Version of Celiac Disease Questionnaire (CDQ); A Specific Questionnaire to Measure Quality of Life of Iranian Patients

Background: The assessment of health-related quality of life has become an important primary or secondary outcome measure in clinical and epidemiologic studies. The aim of this study was to validate a Persian version of Celiac Disease Questionnaire (CDQ) for Celiac disease (CD) among Iranian patients.

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Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis

Background:  To investigate whether aggressive hydration can increase the efficacy of prophylactic non-steroid anti-inflammatory drugs (NSAIDs) in prevention of post-ERCP pancreatitis. NSAIDs are recommended for the prevention of PEP; however, whether aggressive hydration can have additional benefits in this regard is not known.

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Promising effect of rapamycin on multiple sclerosis

Background: The routine therapies for relapsing-remitting multiple sclerosis (RRMS) are common disease-modifying medications, yet are not effective in all patients. The aim of the present clinical trial was to evaluate the therapeutic effects of rapamycin on the clinical and radiological aspects, regulatory T cells proliferation and FOXP3 and GARP gene expression in the patients with RRMS.

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Establishment and Development of the First Biobank of Inflammatory Bowel Disease, Suspected to Primary Immunodeficiency Diseases in Iran

Background: Inflammatory bowel disease (IBD) might be an immunodeficiency rather than an excessive inflammatory reaction. IBD, suspected to primary immunodeficiency diseases biobank (IBDSPIDB) as a resource for researches can help improve the prevention, diagnosis, and illness treatment and the health promotion throughout the society. Therefore, we launched the biobank of IBDSPID for the first time in Iran.

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Assessment of anemia in patients with various types of inflammatory bowel disease under medical therapy

Background: Anemia is a usual systemic complication of inflammatory bowel disease (IBD) and can be presented in combination of iron deficiency anemia (IDA) and anemia of chronic disease (ACD). In the present study, anemia in IBD was assessed.

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Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Background: Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences. It is due to DNA‑mismatch‑repair system deficiency because of a germline/somatic mutation in mismatch‑repair (MMR) genes. The germline mutations lead to Lynch syndrome (LS) while epigenetic gene silencing results in sporadic CRC tumors. 

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Transcultural Adaptation and Validation of Persian Version of Celiac Disease Questionnaire (CDQ); A Specific Questionnaire to Measure Quality of Life of Iranian Patients

Background: The assessment of health-related quality of life has become an important primary or secondary outcome measure in clinical and epidemiologic studies. The aim of this study was to validate a Persian version of Celiac Disease Questionnaire (CDQ) for Celiac disease (CD) among Iranian patients.

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Promising effect of rapamycin on multiple sclerosis
Combination of diclofenac and aggressive hydration for the prevention of post-ERCP pancreatitis

Background: To investigate whether aggressive hydration can increase the efficacy of prophylactic non-steroid anti-inflammatory drugs (NSAIDs) in prevention of post-ERCP pancreatitis.
NSAIDs are recommended for the prevention of PEP; however, whether aggressive hydration can have additional benefits in this regard is not known.

 

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Comparison of Sub acromial Ketorolac Injection versus Corticosteroid Injection in the Treatment of Shoulder Impingement Syndrome

Background: Subacromial impingement syndrome is the most common cause of shoulder pain and restriction in range of motion in the world. The aim of this study was to compare the efficacy of subacromial injection of ketorolac with the injection of corticosteroid for the treatment of subacromial impingement syndrome.

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Predicting Factors for the Communication between hydatid Cyst and Biliary Tract

Background: Hydatid cyst communicated with biliary tract increases the morbidity and mortality rates. Therefore, early detection and treatment are vital.

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Quality of life in inflammatory bowel disease patients: A cross‑sectional study

Background: Inflammatory bowel disease (IBD) has a significant impact on health‑related quality of life (HRQOL). This study aims to investigate the variables which can be attributed to HRQOL in IBD patients.

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Familial Colorectal Cancer Type X in Central Iran: A New Clinic pathologic Description

Background: Familial colorectal cancer type X (FCCX) is a subtype of mismatchrepair (MMR)-proficient colorectal cancerin whichthe patients are clinicallyat risk for Lynch syndrome (LS), a common hereditary cancer predisposing syndrome.In this study, we describeda new clinicopathological feature of the condition in central Iran.

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Diagnostic value of alarm symptoms for upper GI malignancy in patients referred to GI clinic: A 7 years cross sectional study

Background: Early upper gastrointestinal (UGI) cancer detection had led to organ‑preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy.
 

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Simplified microsatellite instability detection protocol provides equivalent sensitivity to robust detection strategies in Lynch syndrome patients

Background: Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome (LS). LS is an inherited disease, and an important consequence of MMR deficiency is microsatellite instability (MSI) phenotype. MSI phenotype influences the efficacy of 5 fluorouracil (5-FU) chemotherapy.

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Effects of Ramadan Fasting on Dyspepsia Symptoms

Background: A few studies have shown that during Ramadan, gastrin, pepsin, and acid secretion are increased and some changes in nutrition of fasting people may deteriorate dyspepsia symptoms. On the other hand stopping smoking and alcohol use and probable psychosocial factors may improve dyspepsia symptoms.

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Effectiveness of Quercus brantii hydro alcoholic extract on dyspepsia: A randomized, double blind clinical trial

Background: We aimed to evaluate the effectiveness of hydroalcoholic extract of Quercus brantii’s nut on clinical, endoscopic, and pathological fi ndings of patients with dyspepsia.

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Effect of Ramadan Fasting on Alanine Aminotransferase (ALT) in Non- Alcoholic Fatty Liver Disease (NAFLD)

Background: Early upper gastrointestinal (UGI) cancer detection had led to organ‑preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy. This study is designed to see whether using alarm symptoms can predict the risk of cancer in patients.

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Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic. For MSI detection, immunohistochemistry or PCR-based protocols using a cohort of various sets of STR markers are recommended. Here we aimed to evaluate a simplified protocol using just a single STR marker, MT1XT20 mononucleotide repeat, for detection of MSI in Lynch syndrome patients. A Promega five-marker MSI testing panel and immunohistochemistry (IHC) were used as the gold standard in conjunction with MT1XT20.

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Effects of Physical Activity on Risk of Colorectal Cancer: A Case–control Study

Background: The prevalence of colorectal cancer (CRC) is rapidly increasing in Iran. It holds the most prevalent cancer after skin, breast, and gastric cancers among the Iranian population. The current study was designed to investigate the effects of leisure time, occupational and household physical activity as well as exercise on the risk of CRC in the Iranian population.

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Sleep quality in women with systemic lupus erythematosus:contributing factors and effects on health-related quality of life

Background: Sleep quality disturbances are common in patients with systemic lupus erythematosus (SLE). We evaluated sleep quality and its contributors in women with SLE. Also we evaluated the effects of sleep quality disturbance on patients’ health-related quality of life (HRQoL).

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Effects of Intraperitoneal dministration of Simvastatin in Prevention of Postoperative Intra-abdominal Adhesion Formation in Animal Model of Rat

Background: To determine the preventive effects of local administration of simvastatin for postoperative intraabdominal adhesion formation in animal model of rat.

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Relationship between articular and nonarticular manifestations in inflammatory bowel Diseases

Background: Musculoskeletal manifestations (MSM) of inflammatory bowel diseases (IBDs) are usually the most frequent extraintestinal manifestations. However, they are not paid enough attention during regular office visits. This cross‑sectional study aimed to draw a clinical picture of MSM and their relationships with other findings in patients with IBD.

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Setting up the First Registry for Inflammatory Bowel Disease, Suspected to Primary Immunodeficiency Diseases in Iran

Background: inflammatory bowel disease (IBD) has been considered a hyperinflammatory state due to disturbed interactions between the immune system and the commensal bacterial flora of the gut and suggesting IBD asa primary immunodeficiencies (PID). Therefore a registry launched about IBD, suspected to PID (IBDSPID) for the first time in Iran to raise awareness about this disease, to identify its risk factors, to early diagnosis and treatment.
 

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Effects of Physical Activity on Risk of Colorectal Cancer: A Case–control Study

Background: The prevalence of colorectal cancer (CRC) is rapidly increasing in Iran. It holds the most prevalent cancer after skin, breast, and gastric cancers among the Iranian population. The current study was designed to investigate the effects of leisure time, occupational and household physical activity as well as exercise on the risk of CRC in the Iranian population.
 

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Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic.

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Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Background: Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences. It is due to DNA‑mismatch‑repair system deficiency because of a germline/somatic mutation in mismatch‑repair (MMR) genes. The germline mutations lead to Lynch syndrome (LS) while epigenetic gene silencing results in sporadic CRC tumors.

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Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

 Background: Colorectal cancer (CRC) is becoming one of the most complicated challenges of human health, particularly in developing countries like Iran. In this paper, we try to characterize CRC cases diagnosed < age 50 at-risk for Lynch syndrome within central Iran.

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Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

Background: Microsatellite instability (MSI) is a mutational signature that is the hallmark of Lynch syndrome, and MSI testing is a cost-effective method to screen the disease. Since there is no enough data about MSI status and associated clinicopathologic features of hereditary nonpolyposis colorectal cancer (HNPCC) in Iran, our study is a new trial to describe them in center of Iran (Isfahan)

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Tumor microsatellite instability and clinicopathologic features in Iranian colorectal cancer patients at risk for Lynch syndrome

Background: Microsatellite instability (MSI) is a mutational signature that is the hallmark of Lynch syndrome, and MSI testing is a cost-effective method to screen the disease. Since there is no enough data about MSI status and associated clinicopathologic features of hereditary nonpolyposis colorectal cancer (HNPCC) in Iran, our study is a new trial to describe them in center of Iran (Isfahan).
 

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Linguistic Validation of the M. D. Anderson Symptom Inventory in Persian-Speaking Iranian Cancer Patients

Background:  Various symptoms frequently affect cancer patients’ quality of life. Appropriate assessment of these symptom provides valuable data for cancer managemen.

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Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients

Background: Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients.

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Immunohistochemical analysis of mismatch repair proteins in Iranian colorectal cancer patients at risk for lynch syndrome

Background: Hereditary non-polyposis colorectal cancer (HNPCC) is a common hereditary cancer predisposing syndrome has molecular and clinicopathological features still have remained ambiguous within Iranian populations. We discuss in this article some molecular and clinicopathological features of the condition. 

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Molecular Analysis of Iranian Colorectal Cancer Patients at Risk for Lynch Syndrome: a New Molecular,Clinicopathological Feature

Background: Microsatellite instability (MSI) and mismatch repair (MMR) gene expression present a hallmark mutational signature of Lynch syndrome as a common hereditary cancer predisposing condition. Since there is not enough data of molecular and clinicopathological aspects of the disease in Iranian populations, this article is a new description in Central Iran.

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MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Detection of Microsatellite Instability in Iranian Patients with Hereditary Nonpolyposis Colorectal Cancer (HNPCC).

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary or sporadic, demonstrate better prognosis, altered response to fluorouracil (5FU) chemotherapy and altered operative approach. It is now recommended to perform MSI testing for all new cases of colorectal cancers regardless of being categorized as hereditary or sporadic. This study aimed to evaluate MT1XT20 mononucleotide marker in Iranian patients with hereditary nonpolyposis colorectal cancer (HNPCC). The samples were further characterized using Promega five-marker MSI testing panel and immunohistochemical (IHC) technique.

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Health related quality of life in irritable bowel syndrome patients, Kashan, Iran: A case control study

Background: Irritable bowel syndrome has significant impacts on the quality of life (QOL) but IBS subtypes may be different in QOL. This study aimed to assess QOL in IBS subtypes and also two prevalent questionnaires applied to evaluate the QOL in IBS.

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Synbiotic containing Bacillus coagulans and fructo-oligosaccharides for functional abdominal pain in children

Background: We evaluated the effectiveness of a synbiotic in the treatment of childhood functional abdominal pain (FAP). Probiotics are effective in the treatment of functional gastrointestinal disorders in adult patients, but there is lack of information in children.

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Evaluation of The Mean Percentages of The Peripheral Blood Gamma Delta T Lymphocytes in The Healthy Subjects and Celiac Patients in Isfahan

Background: An elevation in the mean percentages of the gamma delta T lymphocytes per total T cells in the epithelium of the small intestine has a diagnostic value for celiac disease. This study aimed to measure the percentages of the peripheral blood gamma delta T lymphocytes in the adults' celiac disease and healthy controls.

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Phenotypical characterization of the peripheral blood T cells in patients with celiac disease: does it differentiate suspicious celiac disease cases?

Background: The present study aimed to study the immunological changes seen in the intestinal epithelium of the celiac patients could also be detected in the peripheral blood lymphocyte populations. Celiac disease (CD) is a small bowel enteropathy caused by permanent wheat gluten intolerance. One of the earliest signs of CD is an increase in the numbers of the intestinal intraepithelial lymphocytes (iIEL).

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Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases

Background: Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD). Aims To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients.

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Evaluating the Validity and Reliability of Persian Version of Lupus Quality of Life (LupusQol) Questionnaire in Iranian Patients

Background: Quality of life is of the most important outcomes measured in patients with systemic lupus erythematosus (SLE). The Lupus Quality of Life (LupusQoL) questionnaire is designed to specifically assess quality of life in these patients. This study aimed to evaluate validity and reliability of the Persian version of this questionnaire in Iranian patients.

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Linguistic Validation of the LupusQoL for the Assessment of Quality of Life in Iranian Patients with Systemic Lupus Erythematosus

Background: We evaluated the psychometric properties of the Persian LupusQoL for the evaluation of quality of life in Iranian systemiclupus erythematosus (SLE) patients.

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Magnetic resonance cholangiography compared with endoscopic retrograde cholangiography in the diagnosis of primary sclerosing cholangitis

Background: Magnetic resonance cholangiography (MRC) has gained popularity for diagnosing primary sclerosing cholangitis (PSC). We determined the accuracy of MRC compared with endoscopic retrograde cholangiography (ERC) for diagnosing PSC.

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P wave duration and dispersion in Holter electrocardiography of patients with obstructive sleep apnea

Background: The underlying mechanisms of the association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) remained unclear. We investigated P wave parameters as indicators of atrial conduction status among OSA patients.

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Seropositivity of cytomegalovirus in patients with recurrent pregnancy loss

Background: Some evidence has shown a relationship between human cytomegalovirus (CMV) infection and pregnancy loss. However, whether recurrent or latent CMV infection or altered immune response to CMV is related to recurrent pregnancy loss (RPL) is unclear. We evaluated CMV infection and avidity of antibodies to CMV in women with RPL.

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Sleep disorders in systemic lupus erythematosus. Does vitamin D play a role?

Background: Sleep disorders are common among patients with systemic lupus erythematosus (SLE) with unclear underlying mechanisms. We assessed the role of vitamin D in sleep quality of patients with SLE.

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Premedication with sublingual or oral alprazolam in adults undergoing diagnostic upper gastrointestinal endoscopy

Background: Diagnostic esophagogastroduodenoscopy (EGD) is uncomfortable for most patients. We determined the efficacy of alprazolam, administered orally or sublingually, as premedication for sedation during EGD.

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Citalopram for pediatric functional abdominal pain: a randomized, placebo-controlled trial

Background: Antidepressants are effective in adults with pain-related functional gastrointestinal disorders. We investigated the effectiveness of citalopram in the treatment of childhood functional abdominal pain (FAP).

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Mebeverine for Pediatric Functional Abdominal Pain: A Randomized, Placebo-Controlled Trial

Background: Few studies are conducted on the efficacy of antispasmodics in the treatment of functional gastrointestinal disorders in children. We evaluated the effectiveness of a smooth-muscle relaxant (mebeverine) in the treatment of childhood functional abdominal pain (FAP).

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Premedication with sublingual or oral alprazolam in adults undergoing diagnostic upper gastrointestinal endoscopy

Background: Diagnostic esophagogastroduodenoscopy (EGD) is uncomfortable for most patients. We determined the efficacy of alprazolam, administered orally or sublingually, as premedication for sedation during EGD.

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The involvement of the HLA-DQB1 alleles in the risk and the severity of Iranian coeliac disease patients

Background: Coeliac disease (CD) is a highly prevalent autoimmune disorder that is triggered by the ingestion of wheat gluten and related proteins in genetically susceptible individuals. The CD is associated with human leucocyte antigen (HLA) genes particularly with HLA-DQ alleles encoding HLA-DQ2 and DQ8 proteins.

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Premedication with sublingual or oral alprazolam in adults undergoing diagnostic upper gastrointestinal endoscopy

Background: Diagnostic esophagogastroduodenoscopy (EGD) is uncomfortable for most patients. We determined the efficacy of alprazolam, administered orally or sublingually, as premedication for sedation during EGD.

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sleep and psychological disorders in patients with inflammatory bowel diseases; another potential role of vitamin D deficiency
Pulmonary function tests in ulcerative colitis

Background: Pulmonary impairment in patients suffering ulcerative colitis (UC) has been suggested by several investigators using standard pulmonary function tests (PFTs). This changes in pulmonary function associated with minimal respiratory symptoms have been documented, especially in patients with active disease. The aim of this prospective study was to determine airway resistance and lung volumes in patients with UC who have no respiratory symptoms in comparisons to a healthy control group.

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The status of lead and cadmium in soils of high prevalenct gastrointestinal cancer region of Isfahan

Background: Cadmium and lead compounds are classified as human carcinogens by several regulatory agencies. Twenty five percent of all cancer‑related deaths are attributed to gastrointestinal cancers (GI Ca). We investigated the levels of 2 different heavy metals (Cd and Pb) in the soils of the Lenjanat region, Isfahan province, Central Iran where intensive agriculture is surrounded by different industries like steel and cement‑making factories and mining and gastrointestinal cancers are very common in this province.

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Comparison of Lactobacillus Sporogenes plus mineral oil and mineral oil alone in the treatment of childhood functional constipation

Background: Functional constipation is one of the most prevalent childhood gastrointestinal disorders. We evaluated effects of adding a probiotic to mineral oil in the treatment of functional constipation in children.

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Restless legs syndrome in patients on maintenance hemodialysis and peritoneal dialysis

Background: Restless legs syndrome (RLS) is highly frequent among uremic patients; however, little is known about RLS risk factors in these patients. We evaluated the frequency of RLS and associated risk factors in Iranian patients on maintenance hemodialysis (HD) and peritoneal dialysis (PD).

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The Validity and Reliability of the Persian Version of Kidney Disease Quality of Life Questionnaire-Short Form (KDQOL-SF) in Iranian Patients

Background: Health-related quality of life (HQOL) is greatly impaired in patients with end stage renal disease (ESRD). According to the importance of assessing HQOL in chronic disorders and the need for appropriate and specific instruments in this regard, this study aimed to evaluate the validity and reliability of the Persian version of the kidney disease quality of life questionnaire-short form (KDQOL-SF).

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Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population

Background: Colorectal cancer (CRC) is among the major causes of cancer-related morbidity, mortality, and human health problem worldwide. Single-nucleotide polymorphisms (SNPs) in different genes are reported to be effective in increased risk of CRC in different ethnicpopulation.

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Hereditary nonpolyposis colorectal cancer and familial colorectal cancer in Central part of Iran, Isfahan

Background: There is a lack of data on familial aggregation of colorectal cancer (CRC) in Iran. We aimed to determine the frequency of hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) and to determine the frequency of extracolonic cancers in these families in Isfahan.

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Irritable Bowel Syndrome–like Symptoms in Patients with Inflammatory Bowel Disease in Clinical Remission Phase are Related to Gut Inflammation

Background: Symptoms consistent with irritable bowel syndrome (IBS) are common among IBD patients in remission phase, and clinicians have difficulties in interpreting such symptoms as an ongoing disease activity or a coexistent IBS. We investigated if the assessment of Fecal Calprotectin (FC) could be helpful in this regard

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Frequency of Celiac Disease in Adult Patients with Typical or Atypical Malabsorption Symptoms in Isfahan, Iran

Background: Atypical presentations of celiac disease (CD) have now been shown to be much more common than classical (typical) form. We evaluated the frequency of CD among adult patients with typical or atypical symptoms of CD.

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Serologic celiac disease in patients with inflammatory bowel disease

Background: There is an association of celiac disease (CD) with several gastrointestinal illnesses. We aimed to determine the prevalence of CD in patients with inflammatory bowel disease (IBD) to evaluate the value of the routine serological tests for CD in these patients.

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Should We Look for Celiac Disease among all Patients with Liver Function Test Abnormalities?

 Background: Celiac disease (CD) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (LFT). As there is no precise data from our country in this regard, we investigated the prevalence of CD in patients presenting with abnormal LFT.

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Irritable Bowel Syndrome–like Symptoms in Patients with Inflammatory Bowel Disease in Clinical Remission Phase are Related to Gut Inflammation

Background: Symptoms consistent with irritable bowel syndrome (IBS) are common among IBD patients in remission phase, and clinicians have difficulties in interpreting such symptoms as an ongoing disease activity or a coexistent IBS. We investigated if the assessment of Fecal Calprotectin (FC) could be helpful in this regard

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Serologic celiac disease in patients with inflammatory bowel disease

Background: There is an association of celiac disease (CD) with several gastrointestinal illnesses. We aimed to determine the prevalence of CD in patients with inflammatory bowel disease (IBD) to evaluate the value of the routine serological tests for CD in these patients.

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Effects of Carnitine Supplement on Dyslipidemia and Anemia in Hemodialysis Patients

Background: Carnitine deficiency is a common condition in patients on maintenance hemodialysis that contributes to dyslipidemia, anemia, and poor general health in these patients. We evaluated the effect of oral L-carnitine supplementation on lipid profile, anemia, and quality of life in hemodialysis patients.

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Sirolimus-Based Immunosuppression for Treatment of Cutaneous Warts in Kidney Transplant Recipients

Background: Dermatological complications, especially skin infections, are very common following organ transplantation, and result in a lot of distress in the recipient. Herpes zoster, herpes simplex, and human papillomavirus infections are common infections in kidney transplant recipients, and therapeutic management is usually disappointing in immunosuppression state. We report here 2 cases of kidney transplant recipients who developed diffuse human papillomavirus-induced cutaneous warts with no response to conventional treatments.

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The effects of hypotension on differences between the results of simultaneous venous and arterial blood gas analysis

Background: Analysis of venous blood gas (VBG) can represent arterial blood gas (ABG) analysis in patients with various diseases. The effects of hypotension on differences between the results of simultaneous venous and arterial blood gas analyses were reviewed.

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Vitamin D deficiency and its association with disease activity in new cases of systemic lupus erythematosus

Background: Evidence has shown a relationship between vitamin D deficiency and systemic lupus erythematosus (SLE). We evaluated the frequency of vitamin D deficiency and its association with disease activity in new cases of SLE.

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Efficacy of Simethicone in Preparation Prior to Upper Gastrointestinal Endoscopy

Background: The presence of foam/bubbles in stomach and duodenum is a common problem during esophagogastroduodenoscopy (EGD) that interferes with precise evaluation of the mucosa. We evaluated the effectiveness of simethicone in reducing foam/bubbles in stomach and duodenum, endoscopy duration, and patient satisfaction.

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Simethicone for the Preparation before Esophagogastroduodenoscopy

Background: The presence of air bubbles and foamin stomach and duodenumis a common problem during esophagogastroduodenoscopy (EGD).

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Cost-Effectiveness Analysis of Colorectal Cancer Screening Methods in Iran

Introduction: Screening can prevent colorectal cancer from becoming advanced by early detection of precancerous lesions. Cost-effectiveness analysis of colorectal cancer screening methods is highly necessary due to increased prevalence, decreased age at onset and the limited budget in Iran.

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Linguistic Validation of the Irritable Bowel Syndrome-Quality of Life Questionnaire for Iranian Patients

Background:There is a growing interest of clinical and epidemiological researches in the field of functional gastrointestinal disorders in our society. Accordingly, validated and culturally adapted instruments are required for appropriate measurement of variables specially the quality of life. The aim of our study was the linguistic validation of the Irritable Bowel Syndrome-Quality of Life questionnaire (IBS-QOL) for Iranian IBS patients with Persian language

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Comparing the efficacy of biofeedback and balloon-assisted training in the treatment of dyssynergic defecation

Background: Dyssynergic defecation does not respond appropriately to routine treatments for constipation. Recently, research has shown that biofeedback therapy is useful in anorectal dyssynergia. To compare two treatment modalities for patients experiencing dyssynergic defecation.

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Efficacy of Simethicone in Preparation Prior to Upper Gastrointestinal Endoscopy

Background: The presence of foam/bubbles in stomach and duodenum is a common problem during esophagogastroduodenoscopy (EGD) that interferes with precise evaluation of the mucosa. We evaluated the effectiveness of simethicone in reducing foam/bubbles in stomach and duodenum, endoscopy duration, and patient satisfaction.

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Abnormal Liver Enzymes in Coal Tar Refinery Workers of Isfahan

Background: The effects of occupational exposure on liver function in oil refinery workers are not well known. In this study we evaluated the liver enzyme abnormalities among coal tar refinery workers.

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Flutamide-induced Hepatotoxicity: A Case Report

Background: Flutamide is a non-steroidal antiandrogen commonly used in the treatment of prostate cancer. Severe hepatotoxicity occurs in few patients, yet may be fatal. To date, none of the reported cases of flutamide hepatotoxicity has demonstrated thrombocytopenia and chronic liver disease. We report the case of a 55-year-old male with prostatic adenocarcinoma who developed liver failure after six months of flutamide therapy.

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High dose Senna or Poly Ethylene Glycol (PEG) for elective colonoscopy preparation: a prospective randomized investigator-blinded clinical trial

Background: The aim of this study was to determine the efficacy of two methods of colon preparation for colon cleansing in a randomized controlled trial.

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Linguistic Validation of the Inflammatory Bowel Disease Questionnaire-Short Form (IBDQ-9) in Iranian Population

Background: Quality of life is significantly reduced in patients with inflammatory bowel disease (IBD). As there was no specific instrument for assessment of quality of life of Iranian IBD patients, we aimed to linguistically validate the Inflammatory Bowel Disease Questionnaire-Short Form (IBDQ-9) in Iranian IBD patients.

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Simethicone for the Preparation before Esophagogastroduodenoscopy

Background: The presence of air bubbles and foamin stomach and duodenumis a common problem during esophagogastroduodenoscopy (EGD).

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Comparing Biofeedback Therapy and Balloon Defecation Training in Treatment of Dyssynergic Defecation

Background: Dyssynergic defecation does not respond appropriately to routine treatments of constipation. Recently, researches have shown that biofeedback therapy is useful in anorectal dyssynergia. This study compared two treatment modalities for these patients.

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Metabolic syndrome in menopausal transition: Isfahan Healthy Heart Program, a population based study

Introduction: There is a remarkable increase in cardiovascular disease after menopause. On the other hand, metabolic syndrome as a collection of risk factors has a known effect on cardiovascular diseases. Hormone changes are considered as one of the main relevant factor regarding cardiovascular disease as well as some recognized relationship with metabolic syndrome’s components. This study was carried out in order to search for prevalence of metabolic syndrome during menopausal transition. 

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The Effectiveness of Coping Strategies Training on Symptom Severity, Quality of Life and Psychological Symptoms among Patients with Irritable Bowel Syndrome

Background: Various psychological interventions were considered as part of the treatments of irritable bowel syndrome. However, the effectiveness of coping strategies in improving symptoms of this disease remains unclear. The objective of this study was to assess the effects of coping strategies training in treatment of irritable bowel syndrome (IBS).

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Effects of Weight Loss on Liver Enzyme Abnormalities Among Oil Refinery Workers
New interpretation for diagnostic yield of ileoscopy: a prospective study and a brief review

Background: Lower digestive endoscopy is mostly limited to the cecum without any attempt to penetrate the ileum. One of the probable reasons is the expectation of a low diagnostic yield. This study aimed to examine the feasibility of ileoscopy during colonoscopy and its diagnostic yield

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Which End Point Is More Comprehensive in Refl ecting Changes in Irritable Bowel Syndrome Treatment Trials?
Sonographic fatty liver in overweight and obese children, a cross sectional study in Isfahan

Background: Children’s obesity is a known health problem in the world and is a strong predictor of obesity in adulthood which increases the incidence of related diseases such as metabolic syndrome. According to the MONIKA project by the World Health Organization (WHO), Iran is one of the seven countries with a high rate of child obesity. Fatty liver is an abnormality related to metabolic syndrome, with higher prevalence in obese children according to some previous studies. This study investigates the presence of Sonographic Fatty Liver (SFL) in Iranian obese children in comparison with normal and overweight children.

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Treatment of Nonalcoholic Steatohepatitis in Adults: Present and Future

Background: Nonalcoholic steatohepatitis has become one of the most common liver-related health problems. This condition has been linked to an unhealthy diet and weight gain, but it can also be observed in nonobese people. The standard of care is represented by the lifestyle intervention. However, because this approach has several limitations, such as a lack of compliance, the use of many drugs has been proposed. The first-line pharmacological choices are vitamin E and pioglitazone, both showing a positive effect on transaminases, fat accumulation, and inflammation. 

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Hypnotherapy as an Adjuvant for the Management of Inflammatory Bowel Disease: A Case Report

Background: Idiopathic inflammatory bowel diseases (IBDs) significantly affect the quality of life of sufferers. Improved quality of life and patient symptom management may be achieved through integrating psychological/behavioral interventions with pharmacologic treatments.

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Pneumatic Balloon Dilation Therapy Is as Effective Esophagomyotomy for Achalasia

Background: For many years different treatments have been used for achalasia. However, esophagomyotomy (ESM) and pneumatic balloon dilation (PBD) have been considered the treatments of choice. Despite new research, some controversies still exist.

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Safety and Efficacy of New Glyceryl Trinitrate Suppository Formula: First Double Blind Placebo Controlled Clinical Trial

Background: This study was designed to assess the safety and efficacy of 0.2 percent glyceryl trinitrate suppository form in the healing of chronic anal fissure.

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Endoscopic polypectomy resection of blue rubber bleb nevus lesions in small bowel

Background: Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by cutaneous and gastrointestinal (GI) venous malformations. The treatment of BRBNS is primarily supportive and ablative. Ablative therapy involves endoscopic or surgical treatment of GI venous malformations. We describe a 20-year-old woman who had multiple venous malformations all over the GI tract as well as cutaneous lesions.

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Primary chest wall lymphoma with no history of tuberculous pyothorax: Diagnosis and treatment

Objective: Primary chest wall neoplasm represents only 5% of chest wall neoplasm and among them primary chest wall lymphoma is uncommon.

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Diagnostic Accuracy of IgA anti-Tissue Transglutaminase in Patients Suspected of Having Coeliac Disease in Iran

Background: As there are little data about the sensitivity of the IgA anti-tissue transglutaminase (IgA anti-tTG) antibody test in the clinical practice setting, we evaluated the sensitivity of this serologic test in a group of patients who were suspected of having coeliac disease and had serologic testing performed at commercial laboratories.

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Do endoscopic markers still play a role in diagnosis of celiac disease?
How Frequent is Celiac Disease among Epileptic Patients?

Background: A variety of neurological disorders have been reported in association with celiac disease (CD) including epilepsy, ataxia, neuropathy and multifocal leucoencephalopathy. The purpose of this study was to assess the prevalence of CD among epileptic patients.

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14. Is microscopic colitis a missed diagnosis in diarrhea-predominant Irritable Bowel Syndrome?

Background: There are controversies about the importance of biopsies of normal colon mucosa in the investigation of patients with diarrhea predominant irritable bowel syndrome (IBS). On the other hand, microscopic colitis may be missed based on normal colonoscopy and laboratory examination in this group of patients

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Chronic anal fissure: new approaches to chemical sphincterotomy
Endoscopic polypectomy resection of blue rubber bleb nevus lesions in small bowel

Background: Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by cutaneous and gastrointestinal (GI) venous malformations. The treatment of BRBNS is primarily supportive and ablative. Ablative therapy involves endoscopic or surgical treatment of GI venous malformations. We describe a 20-year-old woman who had multiple venous malformations all over the GI tract as well as cutaneous lesions.

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Is microscopic colitis a missed diagnosis in diarrhea-predominant Irritable Bowel Syndrome?

Background: There are controversies about the importance of biopsies of normal colon mucosa in the investigation of patients with diarrhea predominant irritable bowel syndrome (IBS). On the other hand, microscopic colitis may be missed based on normal colonoscopy and laboratory examination in this group of patients.

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Ramadan fasting and inflammatory bowel disease

Background: Ramadan fasting may induce changes in gastrointestinal physiology. The effect of this fasting on inflammatory bowel disease (IBD) is not known. We conducted a cohort study in the month of Ramadan in 2006 to assess the effect of Ramadan fasting on IBD.

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Achalasia and thyroid disease

Background: To investigate some possible etiologies of achalasia by screening patients with achalasia for some autoimmune diseases such as thyroid disease.

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Are endoscopic findings predictive for the presence of H. pylori infection? What about indirect histologic findings?

Background: It is still controversial whether certain endoscopic features can be used to diagnose Helicobacter pylori related gastritis. Our aim was to determine how macroscopic findings were related to histomorphological changes and the presence of H. pylori in patients undergoing endoscopy.

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Colonoscopic diagnosis of appendiceal intussusception in a patient with intermittent abdominal pain: A case report

Background: Intussusception of the appendix is a rare condition. Most cases are diagnosed during operation of the patients suspected to have appendicitis. In this report we present a seventy one year-old man with a history of periumbilical intermittent abdominal pain for several months.

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A 40 years old woman with monolobar Caroli’s syndrome treated by left hepatic lobectomy

Background: Caroli’s disease (CD) is a rare congenital abnormality characterized by dilatation of intra hepatic bile ducts, which causes stone formation, recurrent cholangitis and higher risk for biliary malignancy. Association of this anomaly with congenital hepatic fibrosis is named Caroli’s syndrome (CS). The monolobar involvement of CS is a very rare condition, curable by partial hepatectomy. We report a 40 year-old woman with recurrent epigastric pain without icterus with normal AST, ALT and alkaline phosphates for 5 years due to left lobe Caroli syndrome which was diagnosed by CT scan and MRCP.

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Does delayed gastric emptying shorten the H pylori eradication period? A double blind clinical trial

Background: To evaluate the gastric emptying inhibitory effects of sugar and levodopa on H pylori eradication period.

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Therapeutic approach to "downhill" esophageal varices bleeding due to superior vena cava syndrome in Behcet's disease: a case report.

Background: One of the rare presentations of superior vena cava syndrome is bleeding of "downhill" esophageal varices (DEV) and different approaches have been used to control it. This is a case report whose DEV was eradicated by band ligation for the first time.

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Where Does Hypnotherapy Stand in the Management of Irritable Bowel Syndrome? A Systematic Review

Background: Irritable bowel syndrome (IBS) is a gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause. Despite its prevalence, there remains a significant lack of efficient medical treatment for IBS to date. However, according to some previous research studies, hypnosis has been shown to be effective in the treatment of IBS. To determine the definite efficacy of hypnosis in the treatment of irritable bowel syndrome.

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Airway resistance in irritable bowel syndrome as measured by impulse oscillometry

Background: Irritable bowel syndrome (IBS) is associated with bronchial asthma. However, published data on airway resistance or impedance in patients with IBS but without any respiratory symptoms are lacking.
 

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Effects of Ramadan fasting on acute upper gastrointestinal bleeding due to peptic ulcer

Background: As, acid negatively affects duodenal and gastric mucosal defense, we designed this study to investigate if fasting during Ramadan can promote peptic ulcer and its complication, acute upper gastrointestinal bleeding.

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