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CANCER DEPARTMENT

Director :

Sayyed Mohammad Hassan Emami.Prof. MD

Research Field Of Interest :

  • Epidemiology researches in in GI cancers (Prevalence, Incidence, risk factors, prognostic factors, surveillance)
  • Basic researches (genetic and epigenetic, pathophysiology, histopathology, immunology, microbiology )
  • Clinical researches (Diagnosis, screening and early detection, treatment)
  • Health care system (economy and load of disease, designing the protocols :diagnostic, therapeutic, primary, secondary, and tertiary prevention, designing controlled interventions and evaluating their cost effectiveness)

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Articles

Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Background: Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences. It is due to DNA‑mismatch‑repair system deficiency because of a germline/somatic mutation in mismatch‑repair (MMR) genes. The germline mutations lead to Lynch syndrome (LS) while epigenetic gene silencing results in sporadic CRC tumors. 
https://www.ncbi.nlm.nih.gov/pubmed/29531926

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Familial Colorectal Cancer Type X in Central Iran: A New Clinic pathologic Description

Background: Familial colorectal cancer type X (FCCX) is a subtype of mismatchrepair (MMR)-proficient colorectal cancerin whichthe patients are clinicallyat risk for Lynch syndrome (LS), a common hereditary cancer predisposing syndrome.In this study, we describeda new clinicopathological feature of the condition in central Iran.
https://www.ncbi.nlm.nih.gov/pubmed/28989591

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Diagnostic value of alarm symptoms for upper GI malignancy in patients referred to GI clinic: A 7 years cross sectional study

Background: Early upper gastrointestinal (UGI) cancer detection had led to organ‑preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy.
 
https://www.ncbi.nlm.nih.gov/pubmed/28717373

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Simplified microsatellite instability detection protocol provides equivalent sensitivity to robust detection strategies in Lynch syndrome patients

Background: Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome (LS). LS is an inherited disease, and an important consequence of MMR deficiency is microsatellite instability (MSI) phenotype. MSI phenotype influences the efficacy of 5 fluorouracil (5-FU) chemotherapy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444926/

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Evaluation of MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Characterizing Microsatellite Instability in Persian Lynch Syndrome Patients

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary (Lynch syndrome) or sporadic, demonstrate better prognosis and altered response to 5FU chemotherapy. It is now recommended to perform MSI testing for all new cases of colorectal cancer regardless of being categorized as hereditary or sporadic. For MSI detection, immunohistochemistry or PCR-based protocols using a cohort of various sets of STR markers are recommended. Here we aimed to evaluate a simplified protocol using just a single STR marker, MT1XT20 mononucleotide repeat, for detection of MSI in Lynch syndrome patients. A Promega five-marker MSI testing panel and immunohistochemistry (IHC) were used as the gold standard in conjunction with MT1XT20.
https://www.ncbi.nlm.nih.gov/pubmed/27797228

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Effects of Physical Activity on Risk of Colorectal Cancer: A Case–control Study

Background: The prevalence of colorectal cancer (CRC) is rapidly increasing in Iran. It holds the most prevalent cancer after skin, breast, and gastric cancers among the Iranian population. The current study was designed to investigate the effects of leisure time, occupational and household physical activity as well as exercise on the risk of CRC in the Iranian population.
 
https://www.ncbi.nlm.nih.gov/pubmed/26952161

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Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer

Background: Microsatellite instability (MSI) is a molecular hallmark for some colorectal cancers (CRCs) in which short tandem repeats are prone to mutations along with DNA sequences. It is due to DNA‑mismatch‑repair system deficiency because of a germline/somatic mutation in mismatch‑repair (MMR) genes. The germline mutations lead to Lynch syndrome (LS) while epigenetic gene silencing results in sporadic CRC tumors.
https://www.ncbi.nlm.nih.gov/pubmed/29531926

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Epidemioclinical Feature of Early-Onset Colorectal Cancer at-Risk for Lynch Syndrome in Central Iran

 Background: Colorectal cancer (CRC) is becoming one of the most complicated challenges of human health, particularly in developing countries like Iran. In this paper, we try to characterize CRC cases diagnosed < age 50 at-risk for Lynch syndrome within central Iran.

https://www.ncbi.nlm.nih.gov/pubmed/26107218

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Tumor microsatellite instability and clinicopathologic features in Iranian colorectal cancer patients at risk for Lynch syndrome

Background: Microsatellite instability (MSI) is a mutational signature that is the hallmark of Lynch syndrome, and MSI testing is a cost-effective method to screen the disease. Since there is no enough data about MSI status and associated clinicopathologic features of hereditary nonpolyposis colorectal cancer (HNPCC) in Iran, our study is a new trial to describe them in center of Iran (Isfahan).
 
https://www.ncbi.nlm.nih.gov/pubmed/25983768

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Linguistic Validation of the M. D. Anderson Symptom Inventory in Persian-Speaking Iranian Cancer Patients

Background:  Various symptoms frequently affect cancer patients’ quality of life. Appropriate assessment of these symptom provides valuable data for cancer managemen.
https://www.ncbi.nlm.nih.gov/pubmed/25980966

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Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients

Background: Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients.
https://www.ncbi.nlm.nih.gov/pubmed/25890844

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Immunohistochemical analysis of mismatch repair proteins in Iranian colorectal cancer patients at risk for lynch syndrome

Background: Hereditary non-polyposis colorectal cancer (HNPCC) is a common hereditary cancer predisposing syndrome has molecular and clinicopathological features still have remained ambiguous within Iranian populations. We discuss in this article some molecular and clinicopathological features of the condition. 
https://www.ncbi.nlm.nih.gov/pubmed/25821566

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Molecular Analysis of Iranian Colorectal Cancer Patients at Risk for Lynch Syndrome: a New Molecular,Clinicopathological Feature

Background: Microsatellite instability (MSI) and mismatch repair (MMR) gene expression present a hallmark mutational signature of Lynch syndrome as a common hereditary cancer predisposing condition. Since there is not enough data of molecular and clinicopathological aspects of the disease in Iranian populations, this article is a new description in Central Iran.
https://www.ncbi.nlm.nih.gov/pubmed/25722176

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MT1XT20 Single Quasi-Monomorphic Mononucleotide Marker for Detection of Microsatellite Instability in Iranian Patients with Hereditary Nonpolyposis Colorectal Cancer (HNPCC).

Background: Colorectal malignancies with high microsatellite instability (MSI-H), either hereditary or sporadic, demonstrate better prognosis, altered response to fluorouracil (5FU) chemotherapy and altered operative approach. It is now recommended to perform MSI testing for all new cases of colorectal cancers regardless of being categorized as hereditary or sporadic. This study aimed to evaluate MT1XT20 mononucleotide marker in Iranian patients with hereditary nonpolyposis colorectal cancer (HNPCC). The samples were further characterized using Promega five-marker MSI testing panel and immunohistochemical (IHC) technique.
http://jims.mui.ac.ir/index.php/jims/article/view/5535

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Premedication with sublingual or oral alprazolam in adults undergoing diagnostic upper gastrointestinal endoscopy

Background: Diagnostic esophagogastroduodenoscopy (EGD) is uncomfortable for most patients. We determined the efficacy of alprazolam, administered orally or sublingually, as premedication for sedation during EGD.
https://www.ncbi.nlm.nih.gov/pubmed/24977401

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The status of lead and cadmium in soils of high prevalenct gastrointestinal cancer region of Isfahan

Background: Cadmium and lead compounds are classified as human carcinogens by several regulatory agencies. Twenty five percent of all cancer‑related deaths are attributed to gastrointestinal cancers (GI Ca). We investigated the levels of 2 different heavy metals (Cd and Pb) in the soils of the Lenjanat region, Isfahan province, Central Iran where intensive agriculture is surrounded by different industries like steel and cement‑making factories and mining and gastrointestinal cancers are very common in this province.
https://www.ncbi.nlm.nih.gov/pubmed/23930117

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Effect of rs6983267 polymorphism in the 8q24 region and rs4444903 polymorphism in EGF gene on the risk of sporadic colorectal cancer in Iranian population

Background: Colorectal cancer (CRC) is among the major causes of cancer-related morbidity, mortality, and human health problem worldwide. Single-nucleotide polymorphisms (SNPs) in different genes are reported to be effective in increased risk of CRC in different ethnicpopulation.
https://www.researchgate.net/publication/51121977_Effect_of_rs6983267_polymorphism_in_the_8q24_region_and_rs4444903_polymorphism_in_EGF_gene_on_the_risk_of_sporadic_colorectal_cancer_in_Iranian_population

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Hereditary nonpolyposis colorectal cancer and familial colorectal cancer in Central part of Iran, Isfahan

Background: There is a lack of data on familial aggregation of colorectal cancer (CRC) in Iran. We aimed to determine the frequency of hereditary nonpolyposis colorectal cancer (HNPCC) and familial colorectal cancer (FCC) and to determine the frequency of extracolonic cancers in these families in Isfahan.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523440/

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Efficacy of Simethicone in Preparation Prior to Upper Gastrointestinal Endoscopy

Background: The presence of foam/bubbles in stomach and duodenum is a common problem during esophagogastroduodenoscopy (EGD) that interferes with precise evaluation of the mucosa. We evaluated the effectiveness of simethicone in reducing foam/bubbles in stomach and duodenum, endoscopy duration, and patient satisfaction.
https://www.sid.ir/En/Journal/ViewPaper.aspx?ID=206951

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Simethicone for the Preparation before Esophagogastroduodenoscopy

Background: The presence of air bubbles and foamin stomach and duodenumis a common problem during esophagogastroduodenoscopy (EGD).
https://www.ncbi.nlm.nih.gov/pubmed/21826120

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Cost-Effectiveness Analysis of Colorectal Cancer Screening Methods in Iran

Introduction: Screening can prevent colorectal cancer from becoming advanced by early detection of precancerous lesions. Cost-effectiveness analysis of colorectal cancer screening methods is highly necessary due to increased prevalence, decreased age at onset and the limited budget in Iran.
https://www.ncbi.nlm.nih.gov/pubmed/21361717

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New interpretation for diagnostic yield of ileoscopy: a prospective study and a brief review

Background: Lower digestive endoscopy is mostly limited to the cecum without any attempt to penetrate the ileum. One of the probable reasons is the expectation of a low diagnostic yield. This study aimed to examine the feasibility of ileoscopy during colonoscopy and its diagnostic yield
https://www.ncbi.nlm.nih.gov/pubmed/21772877

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Endoscopic polypectomy resection of blue rubber bleb nevus lesions in small bowel

Background: Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by cutaneous and gastrointestinal (GI) venous malformations. The treatment of BRBNS is primarily supportive and ablative. Ablative therapy involves endoscopic or surgical treatment of GI venous malformations. We describe a 20-year-old woman who had multiple venous malformations all over the GI tract as well as cutaneous lesions.
https://www.ncbi.nlm.nih.gov/pubmed/18974470

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Primary chest wall lymphoma with no history of tuberculous pyothorax: Diagnosis and treatment

Objective: Primary chest wall neoplasm represents only 5% of chest wall neoplasm and among them primary chest wall lymphoma is uncommon.
https://www.ncbi.nlm.nih.gov/pubmed/19114192

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Rearch projects

Evaluation of Claudin4 expression rate in triple negative breast cancers with immunohistochemistry method and its relationship with some breast cancer prognostic factors

In process

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Evaluation of prolactin receptor expression rate in triple negative breast cancer with immunohistochemistry method and its relationship with some breast cancer prognostic factors

In process

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Evaluation of Androgen receptor expression rate in triple negative breast cancers with immunohistochemistry method and its relationship

In process

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To study the sensitivity and specificity of BAT34CE and BAT26 mononucleotide markers microsatellite instability testing in tumor DNA of the patients at risk for Lynch Synsrome in comparison to the standard Promega kit in Isfahan

In process

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Evaluation and identification of potential MSI and MSS short-tandem repeat identifier markers and optimization of the diagnosis of heredity non-polyposis colorectal cancer syndromes

In process

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Evaluation of sensitivity and specificity of BAT40 and BAT25 mononucleotide markers to detect microsatellite instability in colorectal tumors of HNPCC patients in comparison to promega standard kit.

In Process

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Evaluation of the promoter methylation of MINT1,MINT2, MINT25, MINT31 genes and somatic mutation p. G659fs*41 of RNF43 in gastric cancer

In process

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Spatial variability of heavy metals in soil map units and their relationship with accumulation in plant and animal tissue and incidence of gastrointestinal cancer in Lenjanat region, Isfahan

Cost analysis of colorectal cancer treatment in Isfahan province, July 2012

Cost effectiveness analysis of selected colorectal cancer screening methods in Iran
Direct medical costs of colorectal cancer in Isfahan
Evaluating diagnostic value of barium enema in colorectal tumor and non-tumor lesion

Relation between physical activity and Colorectal cancer at Poursina Institute ,and seyed al shohada
Evaluation of microsatellite instability in hereditary non polyposis colorectal cancer (HNPCC) patients

The evaluation of hMLH1 , hMSH2 and hMSH6 genes mutation in HNPCC patient in Isfahan

Evaluation of Geographical Distribution of Colorectal Cancer in Isfahan during 7 years (1996-2003)
The Epidemiology of Nonhereditary Colorectal Cancer in Isfahan province
To detect the families who have HEREDITARY POLYPOSIS COLORECTAL CANCER (non HNPCC hereditary colorectal cancer) in ISFAHAN and it's influence on future management of individuals who are at risk for them
Investigation of relationship between dietary habits & colorectal cancer risk in Isfahan population - 2004-2005
Quality Of Life in Patients With Colorectal Cancer In Isfahan 2006
Relation between physical activity and colorectal cancer
To assess the epidemiology of nonhereditary colorectal cancer in Isfahan province
Evaluation of Geographical Distribution of Colorectal Cancer in Isfahan during 7 years (1996-2003)

To evaluate the relation between stage and histological differentiation and the 3 and 5-year disease free survival of patients with colon cancer undergone surgery alone in comparison to those who have received adjuvant chemotherapy
Evaluation of three SNP frequency in the genomic DNA samples of colon cancer patients and their correlation with the disease in visited patients in poursina hakim research center of Isfahan
Nucleostemin expression in CD133 + and CD133 cells in patients with colon cancer
Surviving expression in CD133 + and CD133 cells in patients with colorectal cancer
Evaluation of diagnostic value of alarm symptoms, dyspepsia and endoscopy in compared with Biopsy
Evaluation of some microRNA (hsa-mir-510-3p, hsa-mir-548av-5p, hsa-mir-30c-1-3p, hsa-mir-300) expression related to colorectal cancer in normal and tumor tissue samples
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