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IBD DEPARTMENT

Director :

Abodolmahdi Baghaei. MD

Research Field Of Interest :

  • Epidemiology research to establish the prevalence of the disease and Disease Surveillance
  • Basic research (pathophysiology, autoimmune mechanisms, inflammatory processes, genetics);
  • Clinical research (clinical spectrum of IBDs, association with other autoimmune diseases and complications);
  • Challenges of treatment of the disease (psychological impact of the diagnosis on family dynamics and on the acceptance of the treatment and prevention)

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Articles

Establishment and Development of the First Biobank of Inflammatory Bowel Disease, Suspected to Primary Immunodeficiency Diseases in Iran

Background: Inflammatory bowel disease (IBD) might be an immunodeficiency rather than an excessive inflammatory reaction. IBD, suspected to primary immunodeficiency diseases biobank (IBDSPIDB) as a resource for researches can help improve the prevention, diagnosis, and illness treatment and the health promotion throughout the society. Therefore, we launched the biobank of IBDSPID for the first time in Iran.
https://www.ncbi.nlm.nih.gov/pubmed/29657930

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Assessment of anemia in patients with various types of inflammatory bowel disease under medical therapy

Background: Anemia is a usual systemic complication of inflammatory bowel disease (IBD) and can be presented in combination of iron deficiency anemia (IDA) and anemia of chronic disease (ACD). In the present study, anemia in IBD was assessed.
http://jims.mui.ac.ir/index.php/jims/article/view/10351

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Quality of life in inflammatory bowel disease patients: A cross‑sectional study

Background: Inflammatory bowel disease (IBD) has a significant impact on health‑related quality of life (HRQOL). This study aims to investigate the variables which can be attributed to HRQOL in IBD patients.
https://www.ncbi.nlm.nih.gov/pubmed/29026420

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Relationship between articular and nonarticular manifestations in inflammatory bowel Diseases

Background: Musculoskeletal manifestations (MSM) of inflammatory bowel diseases (IBDs) are usually the most frequent extraintestinal manifestations. However, they are not paid enough attention during regular office visits. This cross‑sectional study aimed to draw a clinical picture of MSM and their relationships with other findings in patients with IBD.
https://www.ncbi.nlm.nih.gov/pubmed/27904594

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Setting up the First Registry for Inflammatory Bowel Disease, Suspected to Primary Immunodeficiency Diseases in Iran

Background: inflammatory bowel disease (IBD) has been considered a hyperinflammatory state due to disturbed interactions between the immune system and the commensal bacterial flora of the gut and suggesting IBD asa primary immunodeficiencies (PID). Therefore a registry launched about IBD, suspected to PID (IBDSPID) for the first time in Iran to raise awareness about this disease, to identify its risk factors, to early diagnosis and treatment.
 
https://pdfs.semanticscholar.org/5945/89e5671f4868ab8a263e74598bdab8dd50bd.pdf

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Vitamin D Deficiency Associated with Disease Activity in Patients with Inflammatory Bowel Diseases

Background: Evidence exists on the association between vitamin D deficiency and inflammatory bowel diseases (IBD). Aims To investigate whether vitamin D level is associated with disease activity and quality of life in IBD patients.
https://www.ncbi.nlm.nih.gov/pubmed/26031421

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sleep and psychological disorders in patients with inflammatory bowel diseases; another potential role of vitamin D deficiency

https://www.ncbi.nlm.nih.gov/pubmed/24494848

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Pulmonary function tests in ulcerative colitis

Background: Pulmonary impairment in patients suffering ulcerative colitis (UC) has been suggested by several investigators using standard pulmonary function tests (PFTs). This changes in pulmonary function associated with minimal respiratory symptoms have been documented, especially in patients with active disease. The aim of this prospective study was to determine airway resistance and lung volumes in patients with UC who have no respiratory symptoms in comparisons to a healthy control group.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214017/

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Irritable Bowel Syndrome–like Symptoms in Patients with Inflammatory Bowel Disease in Clinical Remission Phase are Related to Gut Inflammation

Background: Symptoms consistent with irritable bowel syndrome (IBS) are common among IBD patients in remission phase, and clinicians have difficulties in interpreting such symptoms as an ongoing disease activity or a coexistent IBS. We investigated if the assessment of Fecal Calprotectin (FC) could be helpful in this regard
https://www.researchgate.net/publication/235741819_Irritable_bowel_syndrome like_symptoms_in_patientswith_inflammatory_bowel_disease_in_clinicalremission_phase_are_related_to_gut_inflammation

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Serologic celiac disease in patients with inflammatory bowel disease

Background: There is an association of celiac disease (CD) with several gastrointestinal illnesses. We aimed to determine the prevalence of CD in patients with inflammatory bowel disease (IBD) to evaluate the value of the routine serological tests for CD in these patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525033/

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High dose Senna or Poly Ethylene Glycol (PEG) for elective colonoscopy preparation: a prospective randomized investigator-blinded clinical trial

Background: The aim of this study was to determine the efficacy of two methods of colon preparation for colon cleansing in a randomized controlled trial.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214296/

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Linguistic Validation of the Inflammatory Bowel Disease Questionnaire-Short Form (IBDQ-9) in Iranian Population

Background: Quality of life is significantly reduced in patients with inflammatory bowel disease (IBD). As there was no specific instrument for assessment of quality of life of Iranian IBD patients, we aimed to linguistically validate the Inflammatory Bowel Disease Questionnaire-Short Form (IBDQ-9) in Iranian IBD patients.
https://www.researchgate.net/publication/316840443_Validation_of_the_Persian_Version_of_Inflammatory_Bowel_Disease_Questionnaire_in_Patients_Who_Referred_to_Clinics_and_Hospitals_of_Birjand_University_of_Medical_Science_Iran

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Simethicone for the Preparation before Esophagogastroduodenoscopy

Background: The presence of air bubbles and foamin stomach and duodenumis a common problem during esophagogastroduodenoscopy (EGD).
https://www.ncbi.nlm.nih.gov/pubmed/21826120

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Hypnotherapy as an Adjuvant for the Management of Inflammatory Bowel Disease: A Case Report

Background: Idiopathic inflammatory bowel diseases (IBDs) significantly affect the quality of life of sufferers. Improved quality of life and patient symptom management may be achieved through integrating psychological/behavioral interventions with pharmacologic treatments.
https://www.ncbi.nlm.nih.gov/pubmed/19216210

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Chronic anal fissure: new approaches to chemical sphincterotomy

http://jrms.mui.ac.ir/index.php/jrms/article/view/1235

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Endoscopic polypectomy resection of blue rubber bleb nevus lesions in small bowel

Background: Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder characterized by cutaneous and gastrointestinal (GI) venous malformations. The treatment of BRBNS is primarily supportive and ablative. Ablative therapy involves endoscopic or surgical treatment of GI venous malformations. We describe a 20-year-old woman who had multiple venous malformations all over the GI tract as well as cutaneous lesions.
https://www.ncbi.nlm.nih.gov/pubmed/18974470

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Is microscopic colitis a missed diagnosis in diarrhea-predominant Irritable Bowel Syndrome?

Background: There are controversies about the importance of biopsies of normal colon mucosa in the investigation of patients with diarrhea predominant irritable bowel syndrome (IBS). On the other hand, microscopic colitis may be missed based on normal colonoscopy and laboratory examination in this group of patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3484793/

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Ramadan fasting and inflammatory bowel disease

Background: Ramadan fasting may induce changes in gastrointestinal physiology. The effect of this fasting on inflammatory bowel disease (IBD) is not known. We conducted a cohort study in the month of Ramadan in 2006 to assess the effect of Ramadan fasting on IBD.
https://www.ncbi.nlm.nih.gov/pubmed/19405258

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Rearch projects

Prevalence of osteopenia and osteoporosis and related risk factors in patients with inflammatory bowel disease

 In process

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Investigation on the presence of mutation in exon 1,2,3 of interleukin 10 receptor A gene in patients with inflammatory bowel syndrome who suspected to primary immunodeficiency diseases referred to Isfahan University Of Medical Sciences gastrointestinal and immunodeficiency research centers and clinics.
Inflammatory Bowel Disease Registry and Surveillance; Feasibility Study and Application

Prevalence of Metabolic Syndrome in Inflammatory Bowel Disease Patients in Isfahan City in 2015 and 2016
Prevalence and types of anemia in IBD patients in Isfahan between 2015 and 2016
Mycophenolate mefetil is better than purine in the management of inflammatory bowel disease, survey on patients who are intolerant to purine
The role of mycophenolate mofetil in management of inflammatory bowel diseases

Evaluation of health related quality of life (HRQOL) and important factors influencing HRQOL in patients with inflammatory bowel disease, in Esfahan in 2014 and 2015

Evaluation of reliability and validity of quality of life questionnaire of patients with inflammatory bowel disease

Comparative study of the relative frequency of ulcerative colitis in patients with MS and normal population

Study of variance analysis of repeated measures and its application in GNT suppository evaluation in treatment of chronic anal fissure

Preparation and evaluation of physiochemical properties of glyceryl trinitrate suppository for treatment of anal fissure

Evaluation the efficacy of Glyceryl trinitrate (GTN) suppository form on the treatment of chronic anal fissure
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