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CELIAC DEPARTMENT

Director :

Nahid Jamali, Health Policy PHD

Research Field of Interest :

  • Epidemiologic research to estimate the prevalence, incidence and surveillance of disease
  • Basic research (genetic, pathology, physiology &...)
  • Clinical research (prevention, diagnosis, treatment, rehabilitation & supportive care)
  • Health system research (cost-effectiveness, quality improvement, guidelines, public health & policy making)

Members

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Articles

Sherkat R, Rostami S, Yaran M, Emami MH, Saneian H, Tavakoli H, Adibi P, Behnam M, Sheykhbahaei S, Bagherpour B, Khoshnevisan R. Establishment and development of the first biobank of inflammatory bowel disease, suspected to primary immunodeficiency diseases in Iran. Advanced biomedical research. 2018;7.---86

Background: Inflammatory bowel disease (IBD) might be an immunodeficiency rather than an excessive inflammatory reaction. IBD, suspected to primary immunodeficiency diseases biobank (IBDSPIDB) as a resource for researches can help improve the prevention, diagnosis, and illness treatment and the health promotion throughout the society. Therefore, we launched the biobank of IBDSPID for the first time in Iran.

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Evaluation of The Mean Percentages of The Peripheral Blood Gamma Delta T Lymphocytes in The Healthy Subjects and Celiac Patients in Isfahan ---153

Background: An elevation in the mean percentages of the gamma delta T lymphocytes per total T cells in the epithelium of the small intestine has a diagnostic value for celiac disease. This study aimed to measure the percentages of the peripheral blood gamma delta T lymphocytes in the adults' celiac disease and healthy controls.

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Phenotypical characterization of the peripheral blood T cells in patients with celiac disease: does it differentiate suspicious celiac disease cases? ---154

Background: The present study aimed to study the immunological changes seen in the intestinal epithelium of the celiac patients could also be detected in the peripheral blood lymphocyte populations. Celiac disease (CD) is a small bowel enteropathy caused by permanent wheat gluten intolerance. One of the earliest signs of CD is an increase in the numbers of the intestinal intraepithelial lymphocytes (iIEL).

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Premedication with sublingual or oral alprazolam in adults undergoing diagnostic upper gastrointestinal endoscopy---155

Background: Diagnostic esophagogastroduodenoscopy (EGD) is uncomfortable for most patients. We determined the efficacy of alprazolam, administered orally or sublingually, as premedication for sedation during EGD.

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The involvement of the HLA-DQB1 alleles in the risk and the severity of Iranian coeliac disease patients ---158

Background: Coeliac disease (CD) is a highly prevalent autoimmune disorder that is triggered by the ingestion of wheat gluten and related proteins in genetically susceptible individuals. The CD is associated with human leucocyte antigen (HLA) genes particularly with HLA-DQ alleles encoding HLA-DQ2 and DQ8 proteins.

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Frequency of Celiac Disease in Adult Patients with Typical or Atypical Malabsorption Symptoms in Isfahan, Iran---159

Background: Atypical presentations of celiac disease (CD) have now been shown to be much more common than classical (typical) form. We evaluated the frequency of CD among adult patients with typical or atypical symptoms of CD.

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Serologic celiac disease in patients with inflammatory bowel disease---160

Background: There is an association of celiac disease (CD) with several gastrointestinal illnesses. We aimed to determine the prevalence of CD in patients with inflammatory bowel disease (IBD) to evaluate the value of the routine serological tests for CD in these patients.

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Should We Look for Celiac Disease among all Patients with Liver Function Test Abnormalities? ---161

 Background: Celiac disease (CD) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (LFT). As there is no precise data from our country in this regard, we investigated the prevalence of CD in patients presenting with abnormal LFT.

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Efficacy of Simethicone in Preparation Prior to Upper Gastrointestinal Endoscopy ---162

Background: The presence of foam/bubbles in stomach and duodenum is a common problem during esophagogastroduodenoscopy (EGD) that interferes with precise evaluation of the mucosa. We evaluated the effectiveness of simethicone in reducing foam/bubbles in stomach and duodenum, endoscopy duration, and patient satisfaction.

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Diagnostic Accuracy of IgA anti-Tissue Transglutaminase in Patients Suspected of Having Coeliac Disease in Iran---163

Background: As there are little data about the sensitivity of the IgA anti-tissue transglutaminase (IgA anti-tTG) antibody test in the clinical practice setting, we evaluated the sensitivity of this serologic test in a group of patients who were suspected of having coeliac disease and had serologic testing performed at commercial laboratories.

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Do endoscopic markers still play a role in diagnosis of celiac disease? ---164
How Frequent is Celiac Disease among Epileptic Patients? ---165

Background: A variety of neurological disorders have been reported in association with celiac disease (CD) including epilepsy, ataxia, neuropathy and multifocal leucoencephalopathy. The purpose of this study was to assess the prevalence of CD among epileptic patients.

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Research Projects

Frequency of Celiac Disease among Patients with Irritable Bowel Syndrome

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Soheyla Kouhestani, MD. Ali Gholamrezai, MD. Mahzouni, MD. Hamed Daghaghzade, MD



Frequency of Unrecognized Celiac Disease among Patients with Chronic liver Disease in Iran

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Soheyla Kouhestani,MD. Marziye Hashemi, MD. Peyman Adibi,MD. Tavakoli, MD



Frequency of Celiac Disease in Suspicious Adult Patients in Isfahan

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Soheyla Kouhestani, MD. Somaye Karimi, MD. Hamid Tavakoli, MD. Hamed Daghaghzade, MD. Amin Nemti, MD

 



Determine of relative frequency of celiac disease in anemic patients of unknown etiology or patients with iron deficiency anemia with recurrent or refractory to iron therapy in Isfahan

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Soheyla Kouhestani,MD. Amin Nemati, MD. Najme Tavakol. Fariboez Mokaryan, MD. Somaye Karimi, MD

 



Studying sensitivity and specificity of IgA anti-tissue transglutaminase (tTG) antibody in patients suspicious of celiac disease in Isfahan

PI: Seyed Mohammad Hassan Emami, MD
Colleagues: Somaye Karimi, MD. Soheyla Kouhestani, MD. Marzye Hashemi. Hajar Taheri

 



Frequency of Celiac Disease in Suspicious Children and Adolescents In Isfahan

PI: Seyed Mohammad Hassan Emami,MD
Colleagues: Soheyla Kouhestani, MD. Somaye Karimi, MD

 



The effect of self care program on the quality of children’s life with Celiac disease at Isfahan celiac Association in 2016-2017

PI: Zahra Ezadi
Colleagues: Shore Zyaei, Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

 



The evaluation Marsh classification, gene expression and serum level of midkine and C-reactive protein in the patients with celiac disease and healthy individuals in Isfahan city

PI: Shima Soltani
Colleagues: Mohsen Masjedi, MD, Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

 



How Frequent is Celiac Disease among Epileptic patients?

PI: Hajar Taheri
Colleagues: Seyed Mohammad Hassan Emami, MD

 



Should We look for Celiac Disease Among all Patients with Liver Test Abnormality?

PI: Marzye Hashemi
Colleagues: Seyed Mohammad Hassan Emami, MD

 



Assessment of the celiac prevalence in cerebellar ataxic patients in Isfahan city

PI: Sepideh Alahdadian
Colleagues: Mohammad Reza Najafi, MD, Seyed Mohammad Hassan Emami, MD
Funded by: Poursina Hakim Digestive Disease Research Center, Isfahan University of Medical Sciences

 



Frequency of Celiac Disease among Epilepsy in Isfahan

PI: Seyed Mohamad Hassan Emami, MD
Colleagues: Hajar Taheri, MD. Soheyla Kouhestani, MD. Masoud Etemadifar. Ahmad Chitsaz. Saaid Karimi. Marzye Hashemi

 



Evaluation the association of HLA-DQb alleles with celiac disease in Iranian population

PI: Mehdi Zamani, MD
Colleagues: Seyed Mohammad Hassan Emami, MD. Seyed Mehran Modares Sadeghi. Vajihe Ostadi. Soheyla Kouhestani, MD

 



Frequency of Celiac Disease in Suspicious Children and Adolescents In Isfahan

PI: Seyed Mohammad Hassan Emami,MD
Colleagues: Soheyla Kouhestani, MD. Somaye Karimi, MD



Comparison of the quantity, phenotype and activity mode of epithelial and lamina propria lymphocytes in duodenum of celiac patients and control group in Isfahan

PI: Mohsen Masjedi, MD
Colleagues: Hadi Nataj. Seyed Mohammad Hassan Emami, MD. Fereshteh Saheb Fosoul



Evaluation of genes involved in celiac disease in affected patients in Isfahan province using NGC (Next Generation Sequence) method

PI: Ghazale Fatemi
Colleagues: Mansour Salehi, MD, Seyed Mohammad Hassan Emami, MD
Funded by: Tehran Islamic Azad University Research Center

 



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