Sherkat R, Rostami S, Yaran M, Emami MH, Saneian H, Tavakoli H, Adibi P, Behnam M, Sheykhbahaei S, Bagherpour B, Khoshnevisan R. Establishment and development of the first biobank of inflammatory bowel disease, suspected to primary immunodeficiency diseases in Iran. Advanced biomedical research. 2018;7.
Background: Inflammatory bowel disease (IBD) might be an immunodeficiency rather than an excessive inflammatory reaction. IBD, suspected to primary immunodeficiency diseases biobank (IBDSPIDB) as a resource for researches can help improve the prevention, diagnosis, and illness treatment and the health promotion throughout the society. Therefore, we launched the biobank of IBDSPID for the first time in Iran.
Evaluation of The Mean Percentages of The Peripheral Blood Gamma Delta T Lymphocytes in The Healthy Subjects and Celiac Patients in Isfahan
Background:An elevation in the mean percentages of the gamma delta T lymphocytes per total T cells in the epithelium of the small intestine has a diagnostic value for celiac disease. This study aimed to measure the percentages of the peripheral blood gamma delta T lymphocytes in the adults' celiac disease and healthy controls.
Phenotypical characterization of the peripheral blood T cells in patients with celiac disease: does it differentiate suspicious celiac disease cases?
Background:The present study aimed to study the immunological changes seen in the intestinal epithelium of the celiac patients could also be detected in the peripheral blood lymphocyte populations. Celiac disease (CD) is a small bowel enteropathy caused by permanent wheat gluten intolerance. One of the earliest signs of CD is an increase in the numbers of the intestinal intraepithelial lymphocytes (iIEL).
Premedication with sublingual or oral alprazolam in adults undergoing diagnostic upper gastrointestinal endoscopy
Background: Diagnostic esophagogastroduodenoscopy (EGD) is uncomfortable for most patients. We determined the efficacy of alprazolam, administered orally or sublingually, as premedication for sedation during EGD.
The involvement of the HLA-DQB1 alleles in the risk and the severity of Iranian coeliac disease patients
Background: Coeliac disease (CD) is a highly prevalent autoimmune disorder that is triggered by the ingestion of wheat gluten and related proteins in genetically susceptible individuals. The CD is associated with human leucocyte antigen (HLA) genes particularly with HLA-DQ alleles encoding HLA-DQ2 and DQ8 proteins.
Frequency of Celiac Disease in Adult Patients with Typical or Atypical Malabsorption Symptoms in Isfahan, Iran
Background:Atypical presentations of celiac disease (CD) have now been shown to be much more common than classical (typical) form. We evaluated the frequency of CD among adult patients with typical or atypical symptoms of CD.
Serologic celiac disease in patients with inflammatory bowel disease
Background:There is an association of celiac disease (CD) with several gastrointestinal illnesses. We aimed to determine the prevalence of CD in patients with inflammatory bowel disease (IBD) to evaluate the value of the routine serological tests for CD in these patients.
Should We Look for Celiac Disease among all Patients with Liver Function Test Abnormalities?
Background:Celiac disease (CD) has been found in up to 10% of the patients presenting with unexplained abnormal liver function tests (LFT). As there is no precise data from our country in this regard, we investigated the prevalence of CD in patients presenting with abnormal LFT.
Efficacy of Simethicone in Preparation Prior to Upper Gastrointestinal Endoscopy
Background: The presence of foam/bubbles in stomach and duodenum is a common problem during esophagogastroduodenoscopy (EGD) that interferes with precise evaluation of the mucosa. We evaluated the effectiveness of simethicone in reducing foam/bubbles in stomach and duodenum, endoscopy duration, and patient satisfaction.
Diagnostic Accuracy of IgA anti-Tissue Transglutaminase in Patients Suspected of Having Coeliac Disease in Iran
Background: As there are little data about the sensitivity of the IgA anti-tissue transglutaminase (IgA anti-tTG) antibody test in the clinical practice setting, we evaluated the sensitivity of this serologic test in a group of patients who were suspected of having coeliac disease and had serologic testing performed at commercial laboratories.
How Frequent is Celiac Disease among Epileptic Patients?
Background: A variety of neurological disorders have been reported in association with celiac disease (CD) including epilepsy, ataxia, neuropathy and multifocal leucoencephalopathy. The purpose of this study was to assess the prevalence of CD among epileptic patients.
Digestive Diseases Research Center (DDRC) is an affiliated research center to Poursina Hakim Institute, a private organization for health promotion, patient care, research and education in biomedical sciences especially field of gastrointestinal diseases. Research activities have been begun since 2000, just at the same time that Poursina Hakim Institute initiated its life. By improving and developing research activities, it was needed to have an organization for making policy and supervise research activities in the institute. Since September 2008, Poursina Hakim Research Center was established for this reason. It was approved by Iranian ministry of health as DDRC in 2015. Our research team is comprises of expert researchers with varying interests and disciplines to translate the research from Bench to Bedside to benefit human health and engage in the development of health related technologies.