grpid =10 مرکز تحقیقات پورسینای حکیم

Simplified microsatellite instability detection protocol provides equivalent sensitivity to robust detection strategies in Lynch syndrome patients

دریافت زمان انتشار : ۱۳۹۶/۰۸/۱۰ تعداد بازدید : 1164 نویسندگان: Hadi Babaei|Mehrdad Zeinalian|Mohammad Hassan Emami|Mortaza Hashemzadeh|Najmeh Farahani|Rasoul Salehi تعداد دانلود : 0 تعداد صفحات : 9

Objective: Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome (LS). LS is an inherited disease, and an important consequence of MMR deficiency is microsatellite instability (MSI) phenotype. MSI phenotype influences the efficacy of 5 fluorouracil (5-FU) chemotherapy. Reproducible, cost effective, and easy to perform laboratory tests are required to include MSI detection in routine laboratory practice. Evaluation of CAT25 as monom

Quality of life in inflammatory bowel disease patients: A cross‑sectional study

دریافت زمان انتشار : ۱۳۹۶/۰۸/۰۶ تعداد بازدید : 1152 نویسندگان: Farzaneh Habibi|Mohammad Emadoddin Habibi|Ali Gharavinia|Sadegh Baradaran Mahdavi|Mohammad Javad Akbarpour|Abdolmehdi Baghaei|Mohammad Hassan Emami تعداد دانلود : 0 تعداد صفحات : 7

Background: Inflammatory bowel disease (IBD) has a significant impact on health‑related quality of life (HRQOL). This study aims to investigate the variables which can be attributed to HRQOL in IBD patients.
Materials and Methods: Seventy‑one patients filled in IBD questionnaire (IBDQ‑32), Pittsburgh sleep quality index questionnaire, and sociodemographic questionnaire. Disease activity was assessed by Crohn’s disease

Inflammatory Bowel Disease Registry and Monitoring: Feasibility Study and Application (Isfahan Infl ammatory Bowel Disease Surveillance Project)

دریافت زمان انتشار : ۱۳۹۶/۰۸/۰۶ تعداد بازدید : 1154 نویسندگان: Abdolmehdi Baghaei|Mohammad Hassan Emami|Peyman Adibi|Hamid Tavakkoli|Hamed Daghaghzadeh|Babak Tamizifar|Mohammad Javad Akbarpour|Badri Hojjatpour تعداد دانلود : 0 تعداد صفحات : 6

Background: Inflammatory bowel disease (IBD) incidence has been increased in Iran as a developing country. Surveillance is a standard method for accessing valid data about disease epidemiology to make relevant decisions for disease control, prevention, and management. We designed Isfahan IBD Surveillance Project (IISP) to make a surveillance system in this area.
Methods: The project is designed in 3 phases. At the fi rst pha

Familial Colorectal CancerType X in Central Iran: A New Clinicopathologic Description

دریافت زمان انتشار : ۱۳۹۶/۰۸/۰۶ تعداد بازدید : 1150 نویسندگان: Mehrdad Zeinalian|Mahdi Hadian|Morteza Hashemzadeh-chaleshtori|Rasoul Salehi|Mohammad Hassan Emami تعداد دانلود : 0 تعداد صفحات : 6

Background: Familial colorectal cancer type X (FCCX) is a subtype of mismatchrepair (MMR)-proficient colorectal cancerin whichthe patients are clinicallyat risk for Lynch syndrome (LS), a common hereditary cancer predisposing syndrome.In this study, we describeda new clinicopathological feature of the condition in central Iran
 Subjects and Methods: We designed a descriptive, retrospective study to screenat-riskcolorect