Molecular Analysis of Iranian Colorectal Cancer Patients at Risk for Lynch Syndrome: a New Molecular,Clinicopathological Feature

دریافت زمان انتشار : ۱۳۹۵/۱۲/۰۷ تعداد بازدید : 1397 نویسندگان: M. Zeinalian|M. Hashemzadeh-Chaleshtori|M. H. Emami|R. Salehi|A. Naimi|M. Kazemi تعداد دانلود : 0 تعداد صفحات : 10

Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynchsyndrome(LS)isacancersusceptibilitysyndromesecondary to a germline mutation in at least one of the DNA mismatch repair genes (MMRs) including MLH1, MSH2, MSH6, andPMS2 [1]. It leads to accumulate of mutations in other genes responsible to apoptosis and cell cycle control which accelerate some tumorigenesis events [2, 3]. Mutation analysis of MMRs is both time-consuming and expensive because of so heterogeneous mutations in these genes [4]. Two molecular screening tools are commonly being used to detect LS, including microsatellite instability (MSI) testing and immunohistochemical (IHC) staining of MMR proteins. MSI refers to genomic instability of short tandem repeats (STRs), the stretched sequences of 1–5 base pairs ..........